Principal Manufacturing Systems Engineer, Upstream/Downstream Process Automation

Amgen

Confirmed live today High trust

Quick summary

Work type: On-site
Location: Holly Springs, NC
Salary: $160,327–$216,913 / yr
Employment: Full-time
Posted: 42 days ago
Freshness: Confirmed live today
Nearby: 99+ roles within 25 mi

Market check

Salary context

Above market

How this pay compares to similar roles

Similar $170k

This role $189k

$123k $227k

below market most similar roles pay here above market

This role pays more than 70% of similar roles. Most pay $142,500–$197,490 — the blue band above. At the midpoint, this role pays about $189k versus about $170k for comparable roles.

Based on 240 similar postings.

Employer

About Amgen

Amgen is a leading biotechnology company that discovers, develops, manufactures, and delivers innovative human therapeutics, with products addressing conditions such as anemia, bone loss, inflammation, and cancer. Industry: Biotechnology & Pharmaceuticals

Amgen currently has 74 open roles on FindRole.

Listed pay typically runs $136,906–$185,227 across 37 roles with salary data.

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At a glance

TL;DR · Principal Manufacturing Systems Engineer, Upstream/Downstream Process Automation

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The Principal Manufacturing Systems Engineer – Upstream/Downstream Process Automation joins the Facilities & Engineering group to serve as a subject matter expert in automation engineering. This role involves driving innovation, solving complex challenges, and influencing the design and implementation of automation systems for upstream and downstream bioprocessing. Key responsibilities include supporting site design, construction, and operational readiness, executing commissioning and qualification of process equipment, and providing 24/7 onsite troubleshooting. The position requires expertise in the Emerson DeltaV Distributed Control System, Process Control Network design, OPC, Foundation Fieldbus, Profibus, and IO-Link technology. Candidates must navigate biopharmaceutical manufacturing processes, including bioreactors and purification skids, while ensuring compliance with GMP, 21 CFR Part 11, ASTM 2500, S88, S95, and GAMP standards to support robust, scalable drug substance production.

Skills

Emerson DeltaV DCS Process Control OPC Foundation Fieldbus Profibus IO-Link PAT 21 CFR Part 11 ASTM 2500 S88 S95 GAMP GMP cGMP Commissioning & Qualification Process Design Downstream Purification Bioreactors Chromatography UFDF CIP/SIP Data Integrity

What you'll do

Lead the design, commissioning, and qualification of process equipment automation in alignment with GMP requirements.
Develop process control automation solutions primarily utilizing the Emerson DeltaV Distributed Control System (DCS).
Act as the responsible system owner providing 24/7 onsite and on-call troubleshooting for automation systems.
Perform automation change assessments and implement configuration changes to support engineering and process qualification runs.
Lead continuous improvement initiatives to enhance safety, reliability, efficiency, and sustainability of manufacturing unit operations.
Maintain data integrity in accordance with current Amgen and industry standards.
Represent plant automation during audits, regulatory inspections, and global network forums.
Mentor junior engineers and cross-functional teams to develop site technical automation capabilities.

What we're looking for

Must have a Doctorate with 2 years of engineering experience, a Master’s with 4 years, a Bachelor’s with 6 years, or an Associate’s with 10 years.
Must have a High school diploma/GED with 12 years of engineering experience and 2 years of managerial or leadership experience.
Must have experience leading teams, projects, programs, or directing the allocation of resources.
Degree in Electrical Engineering, Computer Science, Chemical Engineering, or Biotech Engineering (preferred).
Extensive experience with Emerson DeltaV, Process Control Network design, Virtual Infrastructure, OPC, Foundation Fieldbus, and Profibus (preferred).
Experience with IO-Link technology, PAT tools, and integrating OEM automation software and field instrumentation (preferred).
In-depth knowledge of industry standards including 21 CFR Part 11, ASTM 2500, S88, S95, GAMP, GDP, and GMP (preferred).
Experience in regulated environments, biopharmaceutical manufacturing processes, and commissioning and qualification (preferred).

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