Principal Scientist – Protein Formulation & Biophysical Characterization (High-Concentration Biologics)

Pfizer

Quick summary

Work type
On-site
Location
Andover, MA
Salary
$106,000–$176,600 / yr
Posted
2 days ago
Nearby
99+ roles within 25 mi

Market check

Salary context

Below market

How this pay compares to similar roles

Similar $190k
This role $141k
$91k most similar roles pay here $249k

This role pays less than 81% of similar roles. Most pay $162,000–$217,211 — the shaded band above. At the midpoint, this role pays about $141k versus about $190k for comparable roles.

Based on 240 similar postings.

Employer

About Pfizer

Pfizer Inc. is one of the world''s largest biopharmaceutical companies, researching, developing, manufacturing, and marketing medicines and vaccines across multiple therapeutic areas including oncology, cardiology, and infectious diseases. Industry: Biopharmaceuticals

Pfizer currently has 23 open roles on FindRole.

Listed pay typically runs $106,000–$176,600 across 23 roles with salary data.

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At a glance

TL;DR · Principal Scientist – Protein Formulation & Biophysical Characterization (High-Concentration Biologics)

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The Principal Scientist role in protein formulation and biophysical characterization is a senior-level position within Pfizer’s biologics and vaccines formulation group. This hands-on scientist will develop innovative strategies for high-concentration biologics, focusing on subcutaneous delivery of complex modalities like mAbs, fusion proteins, and bispecifics. Daily responsibilities include designing experiments to optimize formulations, mitigating risks through advanced characterization techniques, and collaborating with cross-functional teams to implement new technologies. The ideal candidate has a PhD in relevant fields and 3-5 years of industry experience, with expertise in biophysical analysis and data interpretation using tools like DLS, DSC, and SEC-MALS. They should also have a strong background in protein formulation for parenteral biologics and be capable of contributing to external scientific engagement through publications and presentations.

Skills

DLS DSC DSF SEC-MALS NTA CD FTIR fluorescence spectroscopy rheology Python R MATLAB Molecular Dynamics Simulations Machine Learning QSPR Modeling AWS Google Cloud Platform Azure GitHub Jupyter Notebook PostgreSQL MySQL CI/CD

What you'll do

  • Design and execute studies to develop and optimize protein formulations for various biologic modalities.
  • Apply biophysical techniques to assess and mitigate risks in protein formulations.
  • Develop novel formulation strategies and scalable approaches for high-concentration biologics.
  • Build external collaborations with academic and industry partners to advance scientific knowledge.
  • Lead a cross-functional group focused on subcutaneous delivery of biologics, aligning with stakeholders.

What we're looking for

  • PhD in a relevant scientific field with 3–5 years of industry experience in biologics formulation.
  • Expertise in protein formulation for parenteral biologics and hands-on experience with biophysical characterization techniques.
  • Ability to design, execute, and interpret multi-technique characterization studies for complex data analysis.
  • Familiarity with challenges at high concentrations, including viscosity, aggregation, and colloidal instability.
  • Strong background in subcutaneous drug delivery fundamentals and device compatibility issues.
  • Experience leading cross-functional teams and contributing to external scientific engagement through publications and presentations.

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