below marketmost similar roles pay hereabove market
This role pays less than
80%
of similar roles. Most pay
$169,072–$235,750
— the blue band above.
At the midpoint, this role pays about
$159k
versus about
$202k
for comparable roles.
Based on 240 similar postings.
Employer
About AbbVie
AbbVie is a global biopharmaceutical company focused on discovering and delivering innovative medicines and solutions in immunology, oncology, neuroscience, and eye care. Its products include Humira, Skyrizi, and Rinvoq.
AbbVie currently has
145 open roles
on FindRole.
Listed pay typically runs
$109,500–$208,500
across 140 roles with salary data.
The Senior Scientist, siRNA Design and Off-Target Analysis joins the Biotherapeutic and Genetic Medicine department to support siRNA design and off-target assessment. This role involves establishing and optimizing siRNA sequences to enhance knockdown efficacy while reducing off-target liabilities. The successful candidate will build machine learning models based on high-throughput screening data, develop off-target assessment workflows, and integrate transcriptomic and genomic data. Key responsibilities include developing reusable tools and pipelines using Python and R, performing NGS library preparation, and interpreting transcriptomic data to identify biological risks. The position requires expertise in computational biology, RNA biology, and molecular design to solve problems related to nonclinical safety assessments and the development of selective RNA-based therapeutics. The role focuses on translating complex multi-omics data into actionable biological insights for safer therapeutic modalities.
Machine Learning
Deep Learning
Python
Cheminformatics
Generative AI
Molecular Generation
Retrosynthetic Analysis
Pose Prediction
Computational Chemistry
Drug Discovery
Chemical Engineering
Machine Learning
Python
PyTorch
JAX
Deep Learning
Protein Language Models
Generative Modeling
Representation Learning
Multimodal Learning
Geometric Neural Networks
Active Learning
AlphaFold
Biologics Design
Protein Engineering
Drug Discovery
AI
Machine Learning
Python
Agentic AI
Model Training
Post-training
Vulnerability Research
Malware Analysis
Program Analysis
Software Security
Intrusion Detection
Large-scale Data Systems
Systems Software
Security Tooling
Accelerated Computing