Senior Scientist I - II, Computational HitGen / LeadGen

AbbVie

Confirmed live today High trust

Quick summary

Work type
On-site
Location
Chicago, IL
Salary
$109,500–$208,500 / yr
Posted
10 days ago
Freshness
Confirmed live today
Closes
Sep 28, 2126

Market check

Salary context

Below market

How this pay compares to similar roles

Similar $209k
This role $159k
$92k most similar roles pay here $269k

This role pays less than 84% of similar roles. Most pay $177,137–$241,789 — the shaded band above. At the midpoint, this role pays about $159k versus about $209k for comparable roles.

Based on 240 similar postings.

Employer

About AbbVie

AbbVie is a global biopharmaceutical company focused on discovering and delivering innovative medicines and solutions in immunology, oncology, neuroscience, and eye care. Its products include Humira, Skyrizi, and Rinvoq.

AbbVie currently has 141 open roles on FindRole.

Listed pay typically runs $109,500–$208,500 across 131 roles with salary data.

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At a glance

TL;DR · Senior Scientist I - II, Computational HitGen / LeadGen

Senior Scientist I - II, Computational HitGen / LeadGen joins the HGLG team to drive AI-enabled drug discovery across a small molecule portfolio. This role involves identifying, developing, and deploying innovative methods for computational hit generation while collaborating with medicinal chemists and structural biologists. The successful candidate will establish project-relevant criteria, select optimal methodologies, and develop workflows to predict binding affinities, design compounds with specific pharmacological properties, and sample both enumerated and AI-generated chemical spaces. Key responsibilities include evaluating synthetic tractability of designs from generative AI and communicating complex technical rationale to non-specialists. Required expertise includes machine learning, deep learning, cheminformatics, and Python programming. The role focuses on solving challenges in hit and lead generation by utilizing advanced computational tools for molecular design, pose prediction, and retrosynthetic analysis within an early-stage drug discovery context.

What you'll do

  • Identify and establish project-relevant hit and lead criteria in consultation with project teams.
  • Develop and maintain proficiency in cutting-edge computational methods for the HGLG team.
  • Select and deploy the most suitable computational methods to meet specific project goals.
  • Communicate the rationale behind chosen methodologies and how they inform chemical designs to the project team.
  • Develop workflows for predicting binding affinities of diverse chemotypes and designing compounds with specific pharmacological properties.
  • Sample both enumerated and AI-generated chemical spaces to identify potential drug candidates.
  • Evaluate and optimize the synthetic tractability of designs generated from generative AI models.

What we're looking for

  • Degree in chemistry, computer science, machine learning, cheminformatics, or chemical engineering.
  • Experience developing machine learning models related to chemical and biological data (10+ years for BS, 8+ years for MS, 0+ years for PhD).
  • Experience developing machine learning models related to chemical and biological data (12+ years for BS, 10+ years for MS, 4+ years for PhD).
  • Knowledge and experience in modern computational approaches for medicinal chemistry.
  • Expertise using cutting-edge computational approaches built on Machine Learning/Deep learning and Cheminformatics.
  • Ability to implement, debug, and maintain computational tools in common programming languages like Python.
  • Familiarity with AI/ML-enabled molecular generation, pose prediction, affinity prediction, or pharmacological property prediction.
  • Familiarity with retrosynthetic analysis (preferred); experience contributing to molecular design in early-stage drug discovery (preferred).

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