Senior Scientist, Computational Biotherapeutics Engineering

Pfizer

Hybrid Actively hiring Posted this week
Cambridge, MA Posted 4 days ago $93,600$156,000 / year

At a glance

AI generated

TL;DR

Pfizer's BioMedicine Design department seeks a computational scientist specializing in AI/ML methods for protein modeling, representation learning, and generative model development. This role involves implementing cutting-edge workflows for computational protein design, collaborating with machine learning colleagues to train models for antibody developability engineering, and optimizing the computational platform alongside wet lab experts. The ideal candidate will have hands-on experience using modern AI/ML libraries like PyTorch, expertise in protein structure prediction, and a strong background in Python programming. Familiarity with technologies such as AWS or Google Cloud for scaling deep learning workloads is beneficial. This position offers the chance to influence therapeutic discovery by advancing AI-driven design strategies within Pfizer’s expansive R&D framework.

Skills

Python PyTorch NumPy SciPy scikit-learn AWS AlphaFold RFdiffusion ESM-family models Schrödinger Rosetta Molecular Operating Environment (MOE) HPC GPU Slurm CI/CD

What you'll do

  • Implement advanced AI/ML workflows for computational protein design.
  • Design and train AI/ML models for antibody developability engineering.
  • Analyze large datasets to link protein features with pharmaceutical properties.
  • Serve as a technical expert in deep learning models for protein sequence and structure.
  • Communicate complex scientific ideas and model behavior to multidisciplinary teams.

What we're looking for

  • PhD or Master's degree in biochemistry, computational chemistry, biology, machine learning with relevant experience.
  • Demonstrated use of AI/ML for protein modeling/design influencing project strategy.
  • Hands-on experience with modern AI/ML models for protein representation and generation.
  • Strong understanding of protein structure, sequence–structure relationships, and model evaluation.
  • Proficient in Python and scientific or ML libraries like NumPy, scikit-learn, PyTorch.

Employer

About Pfizer

Pfizer Inc. is one of the world''s largest biopharmaceutical companies, researching, developing, manufacturing, and marketing medicines and vaccines across multiple therapeutic areas including oncology, cardiology, and infectious diseases. Industry: Biopharmaceuticals

Pfizer currently has 22 open roles on FindRole.

Listed pay typically runs $106,000–$176,600 across 22 roles with salary data.

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