Senior Scientist, Computational Biotherapeutics Engineering

Pfizer

Confirmed live 2 days ago High trust
Hybrid

Quick summary

Work type
Hybrid
Location
Cambridge, MA
Salary
$93,600–$156,000 / yr
Posted
106 days ago
Freshness
Confirmed live 2 days ago

Market check

Salary context

Below market

How this pay compares to similar roles

Similar $208k
This role $125k
$74k most similar roles pay here $272k

This role pays less than 95% of similar roles. Most pay $166,707–$248,375 — the shaded band above. At the midpoint, this role pays about $125k versus about $208k for comparable roles.

Based on 240 similar postings.

Employer

About Pfizer

Pfizer Inc. is one of the world''s largest biopharmaceutical companies, researching, developing, manufacturing, and marketing medicines and vaccines across multiple therapeutic areas including oncology, cardiology, and infectious diseases. Industry: Biopharmaceuticals

Pfizer currently has 27 open roles on FindRole.

Listed pay typically runs $106,000–$176,600 across 27 roles with salary data.

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View all roles at Pfizer

At a glance

TL;DR · Senior Scientist, Computational Biotherapeutics Engineering

Senior Scientist, Computational Biotherapeutics Engineering joins the BioMedicine Design team to advance biotherapeutic discovery and engineering through advanced computational methods. The role involves implementing and evaluating state-of-the-art AI/ML workflows for protein modeling, representation learning, and generative model development in HPC or cloud environments. You will collaborate with experimental scientists to optimize lead candidates, develop training strategies for new architectures, and analyze large-scale sequence and structure datasets to link protein features to pharmaceutical properties. Key technical requirements include proficiency in Python and libraries such as PyTorch, NumPy, and scikit-learn, alongside experience with transformer or diffusion-based models. The work focuses on solving complex challenges in antibody developability, protein design, and molecular optimization to accelerate the development of clinical molecules within a specialized biotherapeutics research and development framework.

What you'll do

  • Implement advanced AI/ML workflows for computational protein design in HPC or cloud environments.
  • Fine-tune protein language models and develop generative models for protein design.
  • Design and train AI/ML models specifically for antibody developability engineering.
  • Apply machine learning models to optimize leads for antibody drug discovery projects.
  • Analyze large-scale sequence, structure, and experimental datasets to identify features linked to pharmaceutical properties.
  • Serve as a technical expert in deep learning models for protein sequence and structure.
  • Communicate complex scientific ideas and model limitations to both technical and non-technical audiences.
  • Collaborate with wet lab experts to optimize the computational developability platform.

What we're looking for

  • PhD in biochemistry, computational chemistry, computational biology, machine learning, or a related field with 0 to 3 years of experience.
  • Master's degree in biochemistry, computational chemistry, computational biology, machine learning, or a related field with 7 to 8 years of experience.
  • BA/BS degree in biochemistry, computational chemistry, computational biology, machine learning, or a related field with 9 to 11 years of experience.
  • Proven track record using AI/ML-driven protein modeling and design to influence project direction and strategy.
  • Hands-on experience using modern AI/ML models for protein representation, structure prediction, or generation.
  • Proficiency in Python and modern scientific or machine learning libraries like NumPy, SciPy, scikit-learn, and PyTorch.
  • Experience working with large biological datasets and bioinformatics resources.
  • Must have permanent work authorization to be employed in the United States.

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