Principal Scientist-Process Development

Pfizer

Actively hiring
Groton, CT Posted 23 days ago $106,000–$176,600 / year
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At a glance

AI generated

TL;DR

Join our dynamic R&D team as a Senior Peptide Chemist with expertise in enzymatic peptide synthesis and biocatalysis. You will design and execute cutting-edge enzymatic strategies, optimize platforms for peptide bond formation, and collaborate across multidisciplinary teams to advance scalable synthetic technologies. Key responsibilities include enzyme screening, reaction optimization, and documentation of experimental results while adhering to regulatory standards. Ideal candidates hold a PhD in chemistry or related fields with 4+ years of industry experience, strong hands-on skills, and familiarity with peptide synthesis methods. Experience in pharmaceuticals or biotech is preferred, along with proficiency in process-oriented thinking and green chemistry principles. This role offers opportunities for leadership and talent development within a fast-paced environment focused on innovative drug manufacturing processes.

Skills

EnzymeScreening PeptideSynthesis Biocatalysis OrganicChemistry ReactionOptimization DataInterpretation ProcessChemistry GreenChemistry SolidPhasePeptideSynthesis ChemoenzymaticMethods DirectedEvolution ElectronicNotebooks GMPCompliance TechnicalCommunication MultidisciplinaryCollaboration

What you'll do

  • Independently design and optimize enzymatic platforms for peptide bond formation.
  • Execute enzyme screening campaigns, reaction optimization, and scale-up processes.
  • Propose new enzyme-enabled synthetic routes for peptide and API production.
  • Maintain high-quality experimental records in electronic notebooks.
  • Communicate scientific findings to technical and non-technical stakeholders.

What we're looking for

  • PhD in chemistry, chemical biology, biocatalysis, biochemical engineering, or related field with 4+ years of experience.
  • Expertise in enzymatic reactions, biocatalysis, and enzyme-enabled peptide synthesis.
  • Strong experimental skills including reaction optimization, data interpretation, and troubleshooting.
  • Experience with enzyme screening, reaction scale-up, and process-oriented thinking.
  • Industry experience in pharmaceuticals, biotech, or chemical process development preferred.

Market check

Salary context

This $106,000–$176,600 range sits above 10% of similar postings on FindRole.

Peer median band

$140,500–$234,700

Median floor and ceiling across peers.

Typical midpoint (25–75%)

$165,000–$215,150

Middle half of comparable postings.

Based on 240 comparable postings.

* 240 is the maximum number of comparable postings sampled.

Employer

About Pfizer

Pfizer Inc. is one of the world''s largest biopharmaceutical companies, researching, developing, manufacturing, and marketing medicines and vaccines across multiple therapeutic areas including oncology, cardiology, and infectious diseases. Industry: Biopharmaceuticals

Pfizer currently has 18 open roles on FindRole.

Listed pay typically runs $106,000–$176,600 across 18 roles with salary data.

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View all roles at Pfizer

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