AI Engineer, AI+CryoET

Howard Hughes Medical Institute (HHMI)

Confirmed live 2 days ago High trust

Quick summary

Work type
On-site
Location
Ashburn, VA
Salary
$100,178–$125,223 / yr
Posted
11 days ago
Freshness
Confirmed live 2 days ago

Market check

Salary context

Below market

How this pay compares to similar roles

Similar $186k
This role $113k
$85k most similar roles pay here $240k

This role pays less than 96% of similar roles. Most pay $150,249–$222,581 — the shaded band above. At the midpoint, this role pays about $113k versus about $186k for comparable roles.

Based on 240 similar postings.

Employer

About Howard Hughes Medical Institute (HHMI)

Howard Hughes Medical Institute (HHMI) is one of the largest private biomedical research organizations in the world, funding basic research and science education to advance human health and knowledge. Industry: Biomedical Research & Science Education

View all roles at Howard Hughes Medical Institute (HHMI)

At a glance

TL;DR · AI Engineer, AI+CryoET

AI Engineer - AI+CryoET The AI Engineer - AI+CryoET joins the AI@HHMI team to develop machine learning methods for mesoscale structural biology. This role focuses on building supervised and self-supervised deep learning models for particle detection, localization, and structural analysis within cryo-electron tomography data. The primary objective is to identify gold nanoparticle probes and determine the arrangement of nucleosomes in chromatin to understand how macromolecules organize into higher-order structures. Day-to-day responsibilities include designing training pipelines, managing sim-to-real transfer from molecular dynamics simulations, and addressing challenges like missing wedge artifacts and low signal-to-noise conditions. The role requires proficiency in Python, PyTorch, or JAX, along with experience in 3D volumetric image analysis and inverse problems. Candidates will collaborate with structural biologists and cryoET experts to solve complex biological questions regarding cellular organization using high-quality datasets and GPU-based computing environments.

What does a AI Engineer earn in Virginia?

Median $246150 from 70 postings across 3 companies.

See salary data

What you'll do

  • Develop deep learning models to detect and localize gold nanoparticles and macromolecular particles in cryoET data.
  • Create methods to improve tomogram reconstruction by leveraging gold nanoparticle detections to address alignment and noise issues.
  • Design and execute rigorous training pipelines for 3D image analysis, including handling of missing wedge artifacts and CTF effects.
  • Develop supervised and self-supervised models using both simulated and annotated experimental cryoET data.
  • Identify necessary human annotation points and design guided efforts to improve model accuracy.
  • Maintain a well-documented codebase to ensure the reproducibility and expansion of research results.
  • Contribute to scientific publications and present findings at professional conferences.

What we're looking for

  • Master's or PhD in Computer Science, Applied Mathematics, Physics, Computational Chemistry, or a related field.
  • 3+ years of experience training and evaluating deep learning models on 3D or volumetric image data.
  • Proficiency in Python with expertise in PyTorch and/or JAX.
  • Experience with detection, segmentation, or inverse problems in imaging.
  • Ability to reason about neural network behavior from first principles including architecture, regularization, and training procedures.
  • Experience with scalable GPU-based computing on Linux HPC clusters and high-throughput processing for large-scale data.
  • Strong skills in rigorous experimental design, including model comparisons, ablation studies, and reproducibility.
  • Excellent communication skills and ability to work effectively in an interdisciplinary environment.

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