Senior Scientist - Process Modelling

Sanofi

Actively hiring
Framingham Posted 10 days ago

At a glance

AI generated

TL;DR

As a Senior Scientist in Process Modelling at Sanofi's CMC Data Science group, you will join a team dedicated to transforming experimental workflows through digitalization and data analytics. Your primary responsibilities include developing, calibrating, and validating dynamic bioreactor models for optimizing protein production processes, as well as deploying these models in commercial settings to enhance process monitoring and control. You will collaborate closely with cross-functional teams across R&D and manufacturing, ensuring seamless integration of your models into existing workflows while maintaining reproducible computational practices. Ideal candidates hold a PhD or Master's degree in relevant fields and have experience with scientific computing languages like Python, MATLAB, Julia, or R, along with expertise in mammalian cell culture process development and bioreactor engineering principles. This role offers the opportunity to work on cutting-edge AI-driven research that impacts global health outcomes.

Skills

Python MATLAB R Julia mechanistic models dynamic models bioreactor digital twins soft sensors state estimation Kalman filtering moving-horizon estimation model predictive control perfusion bioreactor modeling Oxygen transfer mixing mass transfer CO₂ stripping kLa shear scale-up and scale-down models

What you'll do

  • Develop and validate dynamic models for bioreactor processes to optimize protein production.
  • Deploy digital twins of bioreactors in commercial manufacturing environments for real-time optimization.
  • Maintain reproducible computational workflows using coding, documentation, and version control practices.
  • Communicate model assumptions and limitations to both technical and non-technical stakeholders effectively.
  • Act as a change agent to integrate process modeling into established cell culture development workflows.

What we're looking for

  • PhD in relevant engineering or scientific discipline with 1+ years of experience
  • Develop dynamic models of bioreactor or cell culture processes using ODEs and kinetic rate laws
  • Proficient in Python, MATLAB, Julia, or R for scientific computing
  • Strong understanding of mammalian cell culture process development principles
  • Experience developing and deploying bioreactor digital twins in industrial settings
  • Familiarity with multivariate statistical process monitoring techniques like PCA or PLS
  • Track record of peer-reviewed publications in upstream biopharmaceutical process modeling

Employer

About Sanofi

Sanofi is a French global R&D-driven and AI-powered biopharmaceutical company focused on human health through specialized medicine, vaccines, and consumer healthcare.

Sanofi currently has 18 open roles on FindRole.

Listed pay typically runs $141,000–$203,666 across 6 roles with salary data.

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