Principal Software Engineer
Highnote
Quick summary
Market check
How this pay compares to similar roles
This role pays less than 62% of similar roles. Most pay $161,500–$214,500 — the shaded band above. At the midpoint, this role pays about $169k versus about $188k for comparable roles.
Based on 240 similar postings.
Employer
Regeneron is a leading science-driven biotechnology company that invents, develops, and commercializes life-transforming medicines for serious diseases.
Regeneron currently has 20 open roles on FindRole.
Listed pay typically runs $131,500–$230,200 across 20 roles with salary data.
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At a glance
As a Principal Software Engineer at the Regeneron Genetics Center, you will join a forward-thinking IT team that builds and maintains critical platform tooling and APIs used by research teams to analyze large-scale genetic data. Your day-to-day responsibilities include developing cloud-based data pipelines on AWS, integrating AI tools like Claude Code into development workflows, and collaborating with scientists to deliver robust solutions for scientific discovery. You will need strong experience in API design, RESTful services, and microservices architecture, along with hands-on expertise in Python, TypeScript, Docker, and AWS services. Additionally, familiarity with databases such as PostgreSQL or MySQL, ETL orchestration tools, and AI/ML service integration is essential. This role requires a deep understanding of cloud-native development and the ability to work collaboratively in a high-impact environment focused on advancing genetic research at scale.
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What you'll do
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